Organic Rankine cycles in waste heat recovery: a comparative study

A theoretical study of organic Rankine cycles (ORCs) powered by three different waste heat sources is presented. The heat sources, all found in industrial processes, span a range of energy scales capable of powering ORCs from ∼10 kW to 10 MW. A novel method of pinch point analysis is presented, allowing variable heat input to the ORC. This study models the ORC over a range of operating conditions and with different working fluids for each heat source. Results from each source are compared to assess the influence of different heat source characteristics on optimal ORC design

Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors

Neuronal nicotinic acetylcholine receptors (nAChRs) are a diverse class of ligand-gated ion channels involved in neurological conditions such as neuropathic pain and Alzheimer's disease. α-Conotoxin [A10L]PnIA is a potent and selective antagonist of the mammalian α7 nAChR with a key binding interaction at position 10. We now describe a molecular analysis of the receptor-ligand interactions that determine the role of position 10 in determining potency and selectivity for the α7 and α3β2 nAChR subtypes. Using electrophysiological and radioligand binding methods on a suite of [A10L]PnIA analogs we observed that hydrophobic residues in position 10 maintained potency at both subtypes whereas charged or polar residues abolished α7 binding. Molecular docking revealed dominant hydrophobic interactions with several α7 and α3β2 receptor residues via a hydrophobic funnel. Incorporation of norleucine (Nle) caused the largest (8-fold) increase in affinity for the α7 subtype (Ki = 44 nM) though selectivity reverted to α3β2 (IC50 = 0.7 nM). It appears that the placement of a single methyl group determines selectivity between α7 and α3β2 nAChRs via different molecular determinants

Late-epoch optical and near-infrared observations of the GRB000911 afterglow and its host galaxy

We present the results of an optical and near-infrared (NIR) monitoring campaign of the counterpart of Gamma-Ray Burst (GRB) 000911, located at redshift z=1.06, from 5 days to more than 13 months after explosion. Our extensive dataset is a factor of 2 larger and spans a time interval about 4 times longer than the ones considered previously for this GRB afterglow; this allows a more thorough analysis of its light curve and of the GRB host galaxy properties. The afterglow light curves show a single power-law temporal decline, modified at late times by light from a host galaxy with moderate intrinsic extinction, and possibly by an emerging supernova (SN). The afterglow evolution is interpreted within the classical "fireball" scenario as a weakly collimated adiabatic shock propagating in the interstellar medium. The presence of a SN light curve superimposed on the non-thermal afterglow emission is investigated: while in the optical bands no significant contribution to the total light is found from a SN, the NIR J-band data show an excess which is consistent with a SN as bright as the known hypernova SN1998bw. If the SN interpretation is true, this would be the farthest GRB-associated SN, as well as the farthest core-collapse SN, discovered to date. However, other possible explanations of this NIR excess are also investigated. Finally, we studied the photometric properties of the host, and found that it is likely to be a slightly reddened, subluminous, extreme starburst compact galaxy, with luminosity about 0.1 L*, an age of about 0.5 Gyr and a specific Star Formation Rate (SFR) of approximately 30 Msol yr-1 (L/L*)-1. This is the highest specific SFR value for a GRB host inferred from optical/NIR data.Comment: 13 pages, 6 figures, 3 tables. Accepted for publication in A&A, main journa

The Eighth Data Release of the Sloan Digital Sky Survey: First Data from SDSS-III

The Sloan Digital Sky Survey (SDSS) started a new phase in August 2008, with new instrumentation and new surveys focused on Galactic structure and chemical evolution, measurements of the baryon oscillation feature in the clustering of galaxies and the quasar Ly alpha forest, and a radial velocity search for planets around ~8000 stars. This paper describes the first data release of SDSS-III (and the eighth counting from the beginning of the SDSS). The release includes five-band imaging of roughly 5200 deg^2 in the Southern Galactic Cap, bringing the total footprint of the SDSS imaging to 14,555 deg^2, or over a third of the Celestial Sphere. All the imaging data have been reprocessed with an improved sky-subtraction algorithm and a final, self-consistent photometric recalibration and flat-field determination. This release also includes all data from the second phase of the Sloan Extension for Galactic Understanding and Evolution (SEGUE-2), consisting of spectroscopy of approximately 118,000 stars at both high and low Galactic latitudes. All the more than half a million stellar spectra obtained with the SDSS spectrograph have been reprocessed through an improved stellar parameters pipeline, which has better determination of metallicity for high metallicity stars.Comment: Astrophysical Journal Supplements, in press (minor updates from submitted version

The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since July 2014. This paper describes the second data release from this phase, and the fourteenth from SDSS overall (making this, Data Release Fourteen or DR14). This release makes public data taken by SDSS-IV in its first two years of operation (July 2014-2016). Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey (eBOSS); the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data driven machine learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS website (www.sdss.org) has been updated for this release, and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020, and will be followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14 happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov 2017 (this is the "post-print" and "post-proofs" version; minor corrections only from v1, and most of errors found in proofs corrected

Mendelian randomization provides support for obesity as a risk factor for meningioma.

Little is known about the causes of meningioma. Obesity and obesity-related traits have been reported in several epidemiological observational studies to be risk factors for meningioma. We performed an analysis of genetic variants associated with obesity-related traits to assess the relationship with meningioma risk using Mendelian randomization (MR), an approach unaffected by biases from temporal variability and reverse causation that might have affected earlier investigations. We considered 11 obesity-related traits, identified genetic instruments for these factors, and assessed their association with meningioma risk using data from a genome-wide association study comprising 1,606 meningioma patients and 9,823 controls. To evaluate the causal relationship between the obesity-related traits and meningioma risk, we consider the estimated odds ratio (OR) of meningioma for each genetic instrument. We identified positive associations between body mass index (odds ratio [ORSD] = 1.27, 95% confidence interval [CI] = 1.03-1.56, P = 0.028) and body fat percentage (ORSD = 1.28, 95% CI = 1.01-1.63, P = 0.042) with meningioma risk, albeit non-significant after correction for multiple testing. Associations for basal metabolic rate, diastolic blood pressure, fasting glucose, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, systolic blood pressure, total cholesterol, triglycerides and waist circumference with risk of meningioma were non-significant. Our analysis provides additional support for obesity being associated with an increased risk of meningioma

WIYN Open Cluster Study. XXVI. Improved kinematic membership and spectroscopy of IC 2391

[Abridged] Contex. Young open clusters provide important clues to the interface between the main sequence and pre-main-sequence phases of stellar evolution. The young and nearby open cluster IC 2391 is well-suited to studies of these two evolutionary phases. Aims. We establish a bona fide set of cluster members and then analyze this set in terms of binary frequency, projected rotational velocities, [Fe/H], and lithium abundance. In the wake of the Hipparcos distance controversy for the Pleiades, we compare the main-sequence fitting distance modulus to the Hipparcos mean parallax for IC 2391. Results. The proper-motion survey covers a 6 times larger sky area than the prior targeted searches for cluster members in IC 2391. A total of 66 stars are considered bona fide cluster members down to a mass equivalent to 0.5M_sun. A quarter of them have been newly identified with many in the F2-K5 spectral range, which is crucial for a main-sequence fit. We find a mean [Fe/H] value of +0.06+/-0.06, when a solar abundance of log epsilon (Fe)=7.45 is adopted. The main sequence fitting yields a distance modulus that is 0.19 mag larger than that derived from Hipparcos parallaxes; thus this offset nearly has the size of a similar offset found for the Pleiades. The Li abundance pattern is similar to the earlier findings and is typical for a 40 Myr old open cluster.Comment: 18 pages, 11 figures, Astronomy & Astrophysics, in pres

The S phase checkpoint promotes the Smc5/6 complex dependent SUMOylation of Pol2, the catalytic subunit of DNA polymerase ε

Replication fork stalling and accumulation of single-stranded DNA trigger the S phase checkpoint, a signalling cascade that, in budding yeast, leads to the activation of the Rad53 kinase. Rad53 is essential in maintaining cell viability, but its targets of regulation are still partially unknown. Here we show that Rad53 drives the hyper-SUMOylation of Pol2, the catalytic subunit of DNA polymerase ε, principally following replication forks stalling induced by nucleotide depletion. Pol2 is the main target of SUMOylation within the replisome and its modification requires the SUMO-ligase Mms21, a subunit of the Smc5/6 complex. Moreover, the Smc5/6 complex co-purifies with Pol ε, independently of other replisome components. Finally, we map Pol2 SUMOylation to a single site within the N-terminal catalytic domain and identify a SUMO-interacting motif at the C-terminus of Pol2. These data suggest that the S phase checkpoint regulate Pol ε during replication stress through Pol2 SUMOylation and SUMO-binding abilit